Lighting Up Mislocalized Proteins: Quantum Dot Probes for Multiplexed Cytoplasm-Selective Cell Profiling in Neurodegeneration
Semiconductor quantum dots (QDs) provide unique stability, brightness, and multiplexed capacity for biomarker detection in complex diseases; however, …
Read more…
RNA-binding protein IMP1/ZBP1 directs local translation in microglial processes to regulate motility and phagocytosis during inflammation
Polarized cells in the brain, such as neurons and glia, rely on the asymmetric distribution of their proteins compartmentalizing the function of dendr…
Read more…
TDP-43 dysregulation impairs cholesterol metabolism linked with myelination defects
TDP-43 is a nuclear protein encoded by the TARDBP gene, which forms pathological aggregates in various neurodegenerative diseases, collectively known …
Read more…
Corrigendum to “TDP-43-M323K causes abnormal brain development and progressive cognitive and motor deficits associated with mislocalised and increased levels of TDP-43” [Neurobiology of disease Volume 193, April 2024, 106437]
No abstract…
Read more…
In vivo diagnosis of TDP-43 proteinopathies: in search of biomarkers of clinical use
TDP-43 proteinopathies are a heterogeneous group of neurodegenerative disorders that share the presence of aberrant, misfolded and mislocalized deposi…
Read more…
Author Correction: Genetic-based patient stratification in Alzheimer’s disease
No abstract…
Read more…
Genetic-based patient stratification in Alzheimer’s disease
Alzheimer’s disease (AD) shows a high pathological and symptomatological heterogeneity. To study this heterogeneity, we have developed a patient strat…
Read more…
TDP-43-M323K causes abnormal brain development and progressive cognitive and motor deficits associated with mislocalised and increased levels of TDP-43
TDP-43 pathology is found in several neurodegenerative disorders, collectively referred to as “TDP-43 proteinopathies”. Aggregates of TDP-43 are prese…
Read more…
Leptin haploinsufficiency exerts sex-dependent partial protection in SOD1G93A mice by reducing inflammatory pathways in the adipose tissue
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by significant metabolic disruptions, including weight loss an…
Read more…
Mutation in the FUS nuclear localisation signal domain causes neurodevelopmental and systemic metabolic alterations
Variants in the ubiquitously expressed DNA/RNA-binding protein FUS cause aggressive juvenile forms of amyotrophic lateral sclerosis (ALS). Most FUS mu…
Read more…